Eluxadoline

Chemical formula: C₃₂H₃₅N₅O₅  Molecular mass: 569.662 g/mol  PubChem compound: 11250029

Therapeutic indications

Eluxadoline is indicated for:

Irritable bowel syndrome with diarrhoea (IBS-D)

Population group: only adults (18 years old or older)

Eluxadoline is indicated in adults for the treatment of irritable bowel syndrome with diarrhoea (IBS-D).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Eluxadoline is contraindicated in the following cases:

Alcoholism

Alcoholism

Biliary tree obstruction, pancreatic duct obstruction, Oddi disease or dysfunction

at least one of
Obstruction of biliary tree
Pancreatic duct obstruction
Dysfunction of sphincter of Oddi

Cholecystectomy or agenesis of gallbladder

at least one of
History of cholecystectomy
Congenital absence of gallbladder

Potent inhibitors of OATP1B1

Hepatic organic anion transporting polypeptides 1B1 (OATP1B1) inhibitors

Pancreatitis, structural diseases of the pancreas

at least one of
Congenital malformation of pancreas
Pancreatitis

Hepatic impairment (Child-Pugh Class A-C)

Hepatic insufficiency

Constipation, gastrointestinal obstruction

at least one of
Constipation
Gastrointestinal obstruction

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