Chemical formula: C₃₂H₃₅N₅O₅ Molecular mass: 569.662 g/mol PubChem compound: 11250029
Eluxadoline is a locally acting, mixed mu opioid receptor (μOR) agonist and delta opioid receptor (δOR) antagonist. Eluxadoline is also an agonist at the kappa opioid receptor (κOR). Eluxadoline has demonstrated efficacy in normalizing GI transit and defecation in several models of stress induced or post GI inflammation-altered GI function in animals.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| A07DA06 | A Alimentary tract and metabolism → A07 Antidiarrheals, intestinal antiinflammatory/antiinfective agents → A07D Antipropulsives → A07DA Antipropulsives | |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| VIBERZI Film-coated tablet | FDA, National Drug Code (US) | MPI, US: SPL/PLR | |
| TRUBERZI Film-coated tablet | European Medicines Agency (EU) | MPI, EU: SmPC |
Eluxadoline is an active ingredient of these brands:
United States (US)Canada (CA)Estonia (EE)Lithuania (LT)New Zealand (NZ)Poland (PL)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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