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ATC Group: A07DA Antipropulsives

Anatomical Therapeutic Chemical Classification System

Hierarchical Position

Level
Code
Title
1
A
Alimentary tract and metabolism
2
A07
Antidiarrheals, intestinal antiinflammatory/antiinfective agents
3
A07D
Antipropulsives
4
A07DA
Antipropulsives

Contents

Code
Title
A07DA01
Diphenoxylate
A07DA02
Opium
A07DA03
Loperamide
A07DA04
Difenoxin
A07DA05
Loperamide oxide
A07DA06
Eluxadoline
A07DA52
Morphine, combinations
A07DA53
Loperamide, combinations

Active Ingredients

Chemical substance
Description
Diphenoxylate

Diphenoxylate is a synthetic opioid derivative with selective effects on gastrointestinal smooth muscle. It is essentially devoid of “morphine type subjective effects” at therapeutic doses.

Eluxadoline

Eluxadoline is a locally acting, mixed mu opioid receptor (μOR) agonist and delta opioid receptor (δOR) antagonist. Eluxadoline is also an agonist at the kappa opioid receptor (κOR). Eluxadoline has demonstrated efficacy in normalizing GI transit and defecation in several models of stress induced or post GI inflammation-altered GI function in animals.

Loperamide

By binding to opiate receptors in the gut wall, loperamide hydrochloride reduces propulsive peristalsis, increases intestinal transit time and enhances resorption of water and electrolytes. Loperamide increases the tone of the anal sphincter, which helps reduce faecal incontinence and urgency.

Opium

Opium alkaloids (opioids and isoquinoline derivatives) induce constipation, euphoria, analgesia and sedation dependent on the dose and derivative. The constipating effect is caused by inhibition of the intestines' peristalsis.

Monographs

Monograph
Type
Country
DROPIZOL Oral drops, solution
MPI, EU: SmPC
UK
VIBERZI Film-coated tablet
MPI, US: SPL/PLR
US