Loperamide

Chemical formula: C₂₉H₃₃ClN₂O₂  Molecular mass: 477.038 g/mol  PubChem compound: 3955

Active ingredient description

By binding to opiate receptors in the gut wall, loperamide hydrochloride reduces propulsive peristalsis, increases intestinal transit time and enhances resorption of water and electrolytes. Loperamide increases the tone of the anal sphincter, which helps reduce faecal incontinence and urgency.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
A07DA03 Loperamide A Alimentary tract and metabolism → A07 Antidiarrheals, intestinal antiinflammatory/antiinfective agents → A07D Antipropulsives → A07DA Antipropulsives
Discover more medicines within A07DA03

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
LOPERAMIDE HYDROCHLORIDE Capsules Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
NORIMODE Tablet Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 34552-83-5
CAS Substance: 53179-11-6
DrugBank Drug: DB00836
KEGG Drug: D08144
PubChem Compound: 3955
RxNorm Ingredient: 6468
SNOMED-CT Concept: 387040009
Loperamide (substance)
UNII Identifier: 6X9OC3H4II
LOPERAMIDE

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