Chemical formula: C₂₉H₃₃ClN₂O₂ Molecular mass: 477.038 g/mol PubChem compound: 3955
By binding to opiate receptors in the gut wall, loperamide hydrochloride reduces propulsive peristalsis, increases intestinal transit time and enhances resorption of water and electrolytes. Loperamide increases the tone of the anal sphincter, which helps reduce faecal incontinence and urgency.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| A07DA03 | Loperamide | A Alimentary tract and metabolism → A07 Antidiarrheals, intestinal antiinflammatory/antiinfective agents → A07D Antipropulsives → A07DA Antipropulsives |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| NORIMODE Tablet | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| LOPERAMIDE HYDROCHLORIDE Capsules | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Loperamide is an active ingredient of these brands:
Australia (AU)
Austria (AT)
Brazil (BR)Canada (CA)
Croatia (HR)Cyprus (CY)Ecuador (EC)
Estonia (EE)Finland (FI)
France (FR)
Germany (DE)Hong Kong (HK)
Ireland (IE)
Israel (IL)Japan (JP)
Lithuania (LT)Mexico (MX)
Netherlands (NL)
New Zealand (NZ)
Nigeria (NG)
Poland (PL)Romania (RO)
Singapore (SG)
South Africa (ZA)
Spain (ES)
United Kingdom (UK)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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