ATC Group: A07D Antipropulsives

The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.

Position of A07D in the ATC hierarchy

Level Code Title
1 A Alimentary tract and metabolism
2 A07 Antidiarrheals, intestinal antiinflammatory/antiinfective agents
3 A07D Antipropulsives

Group A07D contents

Code Title
A07DA Antipropulsives

Active ingredients in A07D

Active Ingredient Description

Diphenoxylate is a synthetic opioid derivative with selective effects on gastrointestinal smooth muscle. It is essentially devoid of “morphine type subjective effects” at therapeutic doses.


Eluxadoline is a locally acting, mixed mu opioid receptor (μOR) agonist and delta opioid receptor (δOR) antagonist. Eluxadoline is also an agonist at the kappa opioid receptor (κOR). Eluxadoline has demonstrated efficacy in normalizing GI transit and defecation in several models of stress induced or post GI inflammation-altered GI function in animals.


By binding to opiate receptors in the gut wall, loperamide hydrochloride reduces propulsive peristalsis, increases intestinal transit time and enhances resorption of water and electrolytes. Loperamide increases the tone of the anal sphincter, which helps reduce faecal incontinence and urgency.


Opium alkaloids (opioids and isoquinoline derivatives) induce constipation, euphoria, analgesia and sedation dependent on the dose and derivative. The constipating effect is caused by inhibition of the intestines' peristalsis.

Related product monographs

Title Information Source Document Type  
DROPIZOL Oral drops, solution Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
IMODIUM Capsule Health Products Regulatory Authority (IE) MPI, EU: SmPC
LOMOTIL Tablet Health Products and Food Branch (CA) MPI, CA: SPM
MIRATON Capsule Υπουργείο Υγείας (CY) MPI, EU: SmPC
NORIMODE Tablet Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
VACONTIL Capsule, hard Υπουργείο Υγείας (CY) MPI, EU: SmPC
VACONTIL Tablet Υπουργείο Υγείας (CY) MPI, EU: SmPC
VIBERZI Film-coated tablet FDA, National Drug Code (US) MPI, US: SPL/PLR