Fluconazole

Chemical formula: C₁₃H₁₂F₂N₆O Molecular mass: 306.271 g/mol PubChem compound: 3365

Therapeutic indications

Fluconazole is indicated for:

Coccidioidomycosis

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Coccidioidomycosis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

200-800 mg once a day

200-800 mg once a day

Cryptococcal meningitis

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Cryptococcal meningitis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

200-800 mg once a day

200-800 mg once a day

Invasive candidiasis

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Disseminated candidiasis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

400-800 mg once a day

400-800 mg once a day

Oropharyngeal candidiasis

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

at least one of

Candidiasis of mouth
Pharyngeal candidiasis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

100-400 mg once a day

100-400 mg once a day

Oesophageal candidiasis

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Candidiasis of the esophagus

For this indication, competent medicine agencies globally authorize below treatments (click for details):

100-400 mg once a day

100-400 mg once a day

Candiduria

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Candiduria

For this indication, competent medicine agencies globally authorize below treatments (click for details):

200-400 mg once a day

200-400 mg once a day

Chronic atrophic candidosis

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Chronic atrophic candidosis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

50 mg once a day

50 mg once a day

Chronic mucocutaneous candidiasis

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Chronic mucocutaneous candidiasis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

50-100 mg once a day

50-100 mg once a day

Prophylaxis of oropharyngeal candidiasis in HIV

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Preventive procedure and additionally at least one of

Candidiasis of mouth
Pharyngeal candidiasis

and additionally Human immunodeficiency virus infection

For this indication, competent medicine agencies globally authorize below treatments (click for details):

100-200 mg once a day

200 mg 3 times per week

100-200 mg once a day

200 mg 3 times per week

Prophylaxis of oesophageal candidiasis in HIV

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Preventive procedure and additionally Candidiasis of the esophagus

and additionally Human immunodeficiency virus infection

For this indication, competent medicine agencies globally authorize below treatments (click for details):

100-200 mg once a day

200 mg 3 times per week

100-200 mg once a day

200 mg 3 times per week

Prophylaxis of candidal infections in neutropenia

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Preventive procedure and additionally Candidiasis

and additionally Neutropenia

For this indication, competent medicine agencies globally authorize below treatments (click for details):

200-400 mg once a day

200-400 mg once a day

Prophylaxis of candidal infections in neutropenia

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old)

Preventive procedure and additionally Candidiasis and additionally Neutropenia

For this indication, competent medicine agencies globally authorize below treatments (click for details):

3-12 mg/kg once a day

3-12 mg/kg once a day

Invasive candidiasis

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old)

Disseminated candidiasis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

6-12 mg/kg once a day

6-12 mg/kg once a day

Cryptococcal meningitis

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old)

Cryptococcal meningitis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

6-12 mg/kg once a day

6-12 mg/kg once a day

Mucosal candidiasis

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old)

Mucocutaneous candidiasis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

3-6 mg/kg once a day

3-6 mg/kg once a day

Prophylaxis of candidal infections in neutropenia

Population group: only newborns (0 - 40 days old)

Preventive procedure and additionally Candidiasis

and additionally Neutropenia

For this indication, competent medicine agencies globally authorize below treatments (click for details):

3-12 mg/kg once a day

3-12 mg/kg once a day

Invasive candidiasis

Population group: only newborns (0 - 40 days old)

Disseminated candidiasis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

6-12 mg/kg once a day

6-12 mg/kg once a day

Cryptococcal meningitis

Population group: only newborns (0 - 40 days old)

Cryptococcal meningitis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

6-12 mg/kg once a day

6-12 mg/kg once a day

Mucosal candidiasis

Population group: only newborns (0 - 40 days old)

Mucocutaneous candidiasis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

3-6 mg/kg once a day

3-6 mg/kg once a day

Contraindications

Fluconazole is contraindicated in the following cases:

Medicinal products known to prolong the QT interval and are metabolised via the cytochrome P450 (CYP) 3A4

Drugs prolonging QT interval and additionally CYP3A4 substrates

Terfenadine

Terfenadine

Hypersensitivity to fluconazole

Fluconazole allergy

Cisapride

Cisapride

Astemizole

Astemizole

Pimozide

Pimozide

Quinidine

Quinidine

Erythromycin

Erythromycin

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