Glyceryl trinitrate Other names: Nitro Trinitroglycerin Nitroglycerine

Chemical formula: C₃H₅N₃O₉ Molecular mass: 227.087 g/mol PubChem compound: 4510

Therapeutic indications

Glyceryl trinitrate is indicated for:

Angina pectoris

Population group: only adults (18 years old or older)

For the treatment of angina pectoris and the treatment of variant angina.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

400-1200 μg in 1-3 divided doses

5-15 mg in 1-3 divided doses daily

Chronic anal fissure

Population group: only adults (18 years old or older)

Chronic anal fissure

For this indication, competent medicine agencies globally authorize below treatments (click for details):

3 mg in 2 divided doses daily

Prophylaxis of angina pectoris

Population group: only adults (18 years old or older)

For the prophylaxis of angina pectoris.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

400-800 μg in 1-2 divided doses

5 mg in once a day

Maintenance of venous patency

Population group: only adults (18 years old or older)

Venous access patent

For this indication, competent medicine agencies globally authorize below treatments (click for details):

5 mg in once a day

Unresponsive congestive heart failure

Population group: only adults (18 years old or older)

Unresponsive congestive heart failure, including that secondary to acute myocardial infarction.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

10-100 micrograms/minute

Refractory unstable angina pectoris

Population group: only adults (18 years old or older)

Refractory angina

For this indication, competent medicine agencies globally authorize below treatments (click for details):

10-20 micrograms/minute

Acute coronary insufficiency

Population group: only adults (18 years old or older)

Acute coronary insufficiency

For this indication, competent medicine agencies globally authorize below treatments (click for details):

25-200 micrograms/minute

Myocardial ischemia

Population group: only adults (18 years old or older)

Myocardial ischemia

For this indication, competent medicine agencies globally authorize below treatments (click for details):

25-200 micrograms/minute

Contraindications

Glyceryl trinitrate is contraindicated in the following cases:

Phosphodiesterase type 5 inhibitors

PDE5 selective inhibitors

Acute circulatory failure

Shock

Severe hypotension (systolic blood pressure below 90 mmHg)

Hypotension

Arterial hypoxaemia

Hypoxaemia

Uncorrected hypovolaemia

Hypovolemia

Hypertrophic obstructive cardiomyopathy

Hypertrophic obstructive cardiomyopathy

Toxic pulmonary edema

Toxic pulmonary edema

Cerebral hemorrhage

Cerebral hemorrhage

Increased intracranial pressure

Raised intracranial pressure

Cardiogenic shock

Cardiogenic shock

Severe anaemia

Anemia

Constrictive pericarditis

Constrictive pericarditis

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