Chemical formula: C₉₀H₁₂₀N₂₀O₂₂S₂ Molecular mass: 1,896.833 g/mol PubChem compound: 162462321
Icotrokinra is a peptide that selectively binds to the IL-23 receptor (IL-23R) with a dissociation constant of 7 pM and antagonizes the binding of IL-23. IL-23 is a naturally occurring cytokine that is involved in inflammatory and immune responses. Icotrokinra inhibits the IL-23/IL-23R-dependent release of proinflammatory cytokines.
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Document | Type | Information Source | |
|---|---|---|---|
| ICOTYDE Film-coated tablet | MPI, US: SPL/PLR | FDA, National Drug Code (US) |
Icotrokinra is an active ingredient of these brands:
United States (US)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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