Isosorbide dinitrate Other names: Dilatrate

Chemical formula: C₆H₈N₂O₈ Molecular mass: 236.136 g/mol PubChem compound: 6883

Therapeutic indications

Isosorbide dinitrate is indicated for:

Prophylaxis of angina pectoris

Population group: only adults (18 years old or older)

Prophylaxis and treatment of angina pectoris.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

30-120 mg in 3 divided doses

Angina pectoris

Population group: only adults (18 years old or older)

Angina

For this indication, competent medicine agencies globally authorize below treatments (click for details):

30-120 mg in 3 divided doses

Severe acute or chronic congestive cardiac failure

Population group: only adults (18 years old or older)

As an adjunctive treatment in the management of severe acute or chronic congestive cardiac failure.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

40-240 mg in 4 divided doses

Unresponsive left ventricular failure

Population group: only adults (18 years old or older)

Isosorbide dinitrate is indicated in the treatment of unresponsive left ventricular failure secondary to acute myocardial infarction, unresponsive left ventricular failure of various aetiology and severe or unstable angina pectoris.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

2-20 mg/h

Percutaneous transluminal coronary angioplasty

Population group: only adults (18 years old or older)

Isosorbide dinitrate is indicated during percutaneous transluminal coronary angioplasty to facilitate prolongation of balloon inflation and to prevent or relieve coronary spasm.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

1-5 mg

Contraindications

Isosorbide dinitrate is contraindicated in the following cases:

Riociguat

Riociguat

Phosphodiesterase type-5 inhibitors

at least one of

Tadalafil
Sildenafil
Avanafil
Vardenafil

Cardiogenic shock, hypertrophic obstructive cardiomyopathy, constrictive pericarditis, cardiac tamponade

at least one of

Cardiogenic shock
Hypertrophic obstructive cardiomyopathy
Constrictive pericarditis
Cardiac tamponade

Circulatory collapse, low filling pressure

Shock

Closed angle glaucoma

Angle-closure glaucoma

Aortic valve stenosis, mitral valve stenosis

at least one of

Aortic valve stenosis
Mitral valve stenosis

Severe hypotension (systolic blood pressure less than 90mmHg)

Hypotension

Hypovolaemia

Hypovolemia

Increased intracranial pressure

Raised intracranial pressure

Cerebral haemorrhage, head trauma

at least one of

Cerebral hemorrhage
Injury of head

Anaemia

Anemia

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