Isotretinoin

Also known as: Isotretinoin

Active ingredient description

Isotretinoin is a stereoisomer of all-trans retinoic acid (tretinoin). The exact mechanism of action of isotretinoin has not yet been elucidated in detail, but it has been established that the improvement observed in the clinical picture of severe acne is associated with suppression of sebaceous gland activity and a histologically demonstrated reduction in the size of the sebaceous glands. Furthermore, a dermal anti-inflammatory effect of isotretinoin has been established.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
Isotretinoin
D Dermatologicals → D10 Anti-acne preparations → D10A Anti-acne preparations for topical use → D10AD Retinoids for topical use in acne
Discover more medicines within D10AD04
Isotretinoin
D Dermatologicals → D10 Anti-acne preparations → D10B Anti-acne preparations for systemic use → D10BA Retinoids for treatment of acne
Discover more medicines within D10BA01

Medicines

Isotretinoin is the active ingredient of these drugs:

Drug
Countries

United States

Canada

Spain

South Africa

South Africa

Hong Kong Singapore

Brazil

Italy

Germany Poland

United States

Poland

Austria

United States

Canada

France

France Poland Tunisia

Tunisia

Spain

Australia

Canada

Spain

Italy Spain

Spain

Poland

Italy

Italy

New Zealand

Germany

Poland South Africa

Cyprus

Poland

Poland

Spain

United States

Hong Kong Singapore

Australia Hong Kong New Zealand Singapore South Africa

France

Hong Kong

Australia Estonia France Hong Kong Ireland

Brazil

Australia

Cyprus

Cyprus

Poland

Poland

United States

Isotretinoin is also found within below combination drugs:

ISOTREXIN

Product monographs

Medicine agencies around the world have authorized marketing of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
Summary of Product Characteristics (SPC)
UK
Summary of Product Characteristics (SPC)
UK

Structural formula

Graphic representation of the active ingredient's molecular structure

3D molecular structure

3D representation of the active ingredient's molecular structure

Unique ingredient identifier (UNII)

EH28UP18IF - ISOTRETINOIN

CAS registry number

4759-48-2 - isotretinoin

SNOMED-CT

387208003 - Isotretinoin (substance)