Isotretinoin
Also known as: Isotretinoin
Active ingredient description
Isotretinoin is a stereoisomer of all-trans retinoic acid (tretinoin). The exact mechanism of action of isotretinoin has not yet been elucidated in detail, but it has been established that the improvement observed in the clinical picture of severe acne is associated with suppression of sebaceous gland activity and a histologically demonstrated reduction in the size of the sebaceous glands. Furthermore, a dermal anti-inflammatory effect of isotretinoin has been established.
Medicine classification
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
Product monographs
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
Medicines
Isotretinoin is the active ingredient of these drugs:
United States
Canada
Turkey
Spain
South Africa
South Africa
Ecuador Hong Kong Singapore
Brazil
Italy
Germany Poland
Turkey
United States
Poland
Austria
United States
Canada
France
France Poland Tunisia
Ecuador
Tunisia
Spain
Australia
Canada
Spain
Ecuador
Italy Spain
Spain
Poland
Italy
Ecuador
Ecuador
Italy
New Zealand
Germany
Poland South Africa
Cyprus Ecuador
Poland
Poland
Spain
United States
Ecuador
Hong Kong Singapore
Australia Hong Kong New Zealand Singapore South Africa
France
Hong Kong
Ecuador
Ecuador
Australia Estonia France Hong Kong Ireland
Brazil
Australia
Cyprus
Cyprus
Poland Romania
Ecuador
Poland
United States
Turkey
Isotretinoin is also found within below combination drugs:
Structural formula
Chemical formula: C₂₀H₂₈O₂
Molecular mass: 300.435 g/mol
3D molecular structure