Isotretinoin Other names: Isotretinoin

Chemical formula: C₂₀H₂₈O₂  Molecular mass: 300.435 g/mol  PubChem compound: 5282379

Active ingredient description

Isotretinoin is a stereoisomer of all-trans retinoic acid (tretinoin). The exact mechanism of action of isotretinoin has not yet been elucidated in detail, but it has been established that the improvement observed in the clinical picture of severe acne is associated with suppression of sebaceous gland activity and a histologically demonstrated reduction in the size of the sebaceous glands. Furthermore, a dermal anti-inflammatory effect of isotretinoin has been established.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
D10AD04 Isotretinoin D Dermatologicals → D10 Anti-acne preparations → D10A Anti-acne preparations for topical use → D10AD Retinoids for topical use in acne
Discover more medicines within D10AD04
D10BA01 Isotretinoin D Dermatologicals → D10 Anti-acne preparations → D10B Anti-acne preparations for systemic use → D10BA Retinoids for treatment of acne
Discover more medicines within D10BA01

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
ISOTRETINOIN Capsules, soft Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
ISOTREX Gel Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

3D molecular structure

3D representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 4759-48-2
DrugBank Drug: DB00982
KEGG Drug: D00348
PubChem Compound: 5282379
RxNorm Ingredient: 6064
SNOMED-CT Concept: 387208003
Isotretinoin (substance)
UNII Identifier: EH28UP18IF
ISOTRETINOIN

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