Ivabradine

Chemical formula: C₂₇H₃₆N₂O₅  Molecular mass: 468.594 g/mol  PubChem compound: 132999

Therapeutic indications

Ivabradine is indicated for:

Chronic stable angina pectoris

Population group: only adults (18 years old or older)

Ivabradine is indicated for the symptomatic treatment of chronic stable angina pectoris in coronary artery disease adults with normal sinus rhythm and heart rate ≥70 bpm. Ivabradine is indicated:

  • in adults unable to tolerate or with a contraindication to the use of beta-blockers,
  • or in combination with beta-blockers in patients inadequately controlled with an optimal betablocker dose.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Chronic heart failure NYHA II to IV class with systolic dysfunction

Population group: only adults (18 years old or older)

Ivabradine is indicated in chronic heart failure NYHA II to IV class with systolic dysfunction, in patients in sinus rhythm and whose heart rate is ≥75 bpm, in combination with standard therapy including beta-blocker therapy or when beta-blocker therapy is contraindicated or not tolerated.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Ivabradine is contraindicated in the following cases:

Pregnancy

Pregnancy

Lactation

Lactation

Bradycardia

Bradycardia

Cardiogenic shock

Cardiogenic shock

Acute myocardial infarction

Acute myocardial infarction

Severe hypotension

Hypotension

Severe hepatic insufficiency

Hepatic failure stage IV

Sick sinus syndrome

Sick sinus syndrome

Sino-atrial block

Sinoatrial block

Unstable or acute heart failure

Acute heart failure

Pacemaker dependent

Rhythm from artificial pacing

Unstable angina

Preinfarction syndrome

AV-block of 3rd degree

Complete atrioventricular block

Strong cytochrome P450 3A4 inhibitors

Strong CYP3A4 inhibitors

Verapamil

Verapamil

Diltiazem

Diltiazem

Severe hepatic insufficiency

Hepatic failure stage IV

Get recommendations

Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

Ask the Reasoner

Related medicines

Summary of Product Characteristics (SPC) 2021: PROCORALAN Film-coated tablet
< Previous: Overview
Next: Precautions >

© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.

⇈