Chemical formula: C₉₅H₁₄₆O₂₈ Molecular mass: 1,736.185 g/mol PubChem compound: 46936176
Ivermectin is a member of the avermectin class and has high affinity with glutamate-gated chloride channels present in invertebrate nerve and muscle cells. Its binding to these channels promotes an increase in membrane permeability to chloride ions, leading to hyperpolarization of the neural or muscle cell. This results in neuromuscular paralysis and may lead to the death of certain parasites.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| D11AX22 | D Dermatologicals → D11 Other dermatological preparations → D11A Other dermatological preparations → D11AX Other dermatologicals | |
| P02CF01 | Ivermectin | P Antiparasitic products, insecticides and repellents → P02 Anthelmintics → P02C Antinematodal agents → P02CF Avermectines |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| SOOLANTRA Cream | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| IVERMECTIN SUBSTIPHARM Tablet | MPI, EU: SmPC |
Ivermectin is an active ingredient of these brands:
United States (US)Australia (AU)Canada (CA)Cyprus (CY)Ecuador (EC)Estonia (EE)France (FR)Hong Kong (HK)Ireland (IE)Israel (IL)Japan (JP)Lithuania (LT)Malta (MT)Mexico (MX)Netherlands (NL)New Zealand (NZ)Romania (RO)Singapore (SG)Tunisia (TN)United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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