Ivermectin

Chemical formula: C₉₅H₁₄₆O₂₈  Molecular mass: 1,736.185 g/mol  PubChem compound: 46936176

Active ingredient description

Ivermectin is a member of the avermectin class and has high affinity with glutamate-gated chloride channels present in invertebrate nerve and muscle cells. Its binding to these channels promotes an increase in membrane permeability to chloride ions, leading to hyperpolarization of the neural or muscle cell. This results in neuromuscular paralysis and may lead to the death of certain parasites.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
D11AX22 D Dermatologicals → D11 Other dermatological preparations → D11A Other dermatological preparations → D11AX Other dermatologicals
Discover more medicines within D11AX22
P02CF01 Ivermectin P Antiparasitic products, insecticides and repellents → P02 Anthelmintics → P02C Antinematodal agents → P02CF Avermectines
Discover more medicines within P02CF01

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
IVERMECTIN SUBSTIPHARM Tablet MPI, EU: SmPC
SOOLANTRA Cream Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

External identifiers

CAS Substance: 70288-86-7
DrugBank Drug: DB00602
KEGG Drug: D00804
PubChem Compound: 46936176
RxNorm Ingredient: 6069
SNOMED-CT Concept: 387559003
Ivermectin (substance)
UNII Identifier: 8883YP2R6D
IVERMECTIN

Medicines

Ivermectin is an active ingredient of these brands:

United States (US)

Australia (AU)

Austria (AT)

Canada (CA)

Cyprus (CY)

Finland (FI)

France (FR)

Hong Kong (HK)

Ireland (IE)

Israel (IL)

Japan (JP)

Lithuania (LT)

Mexico (MX)

Netherlands (NL)

New Zealand (NZ)

Poland (PL)

Romania (RO)

Singapore (SG)

Spain (ES)

Tunisia (TN)

Turkey (TR)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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