Levosimendan

Chemical formula: C₁₄H₁₂N₆O  Molecular mass: 280.285 g/mol  PubChem compound: 3033825

Active ingredient description

Levosimendan enhances the calcium sensitivity of contractile proteins by binding to cardiac troponin C in a calcium-dependent manner. Levosimendan increases the contraction force but does not impair ventricular relaxation.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
C01CX08 Levosimendan C Cardiovascular system → C01 Cardiac therapy → C01C Cardiac stimulants excl. cardiac glycosides → C01CX Other cardiac stimulants
Discover more medicines within C01CX08

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
SIMDAX Injection Medicines and Medical Devices Safety Authority (NZ) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 141505-33-1
DrugBank Drug: DB00922
KEGG Drug: D04720
PubChem Compound: 3033825
RxNorm Ingredient: 73107
SNOMED-CT Concept: 442795003
Levosimendan (substance)
UNII Identifier: C6T4514L4E
LEVOSIMENDAN

Medicines

Levosimendan is an active ingredient of these brands:

Austria (AT)

Brazil (BR)

Croatia (HR)

Cyprus (CY)

Estonia (EE)

Finland (FI)

France (FR)

Hong Kong (HK)

Israel (IL)

Lithuania (LT)

Mexico (MX)

New Zealand (NZ)

Poland (PL)

Romania (RO)

Spain (ES)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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