Lofexidine

Chemical formula: C₁₁H₁₂Cl₂N₂O  Molecular mass: 259.132 g/mol  PubChem compound: 30668

Active ingredient description

Lofexidine is a central alpha-2 adrenergic agonist that binds to receptors on adrenergic neurons. This reduces the release of norepinephrine and decreases sympathetic tone. It is used for mitigation of opioid withdrawal symptoms to facilitate abrupt opioid discontinuation in adults.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
N07BC04 Lofexidine N Nervous system → N07 Other nervous system drugs → N07B Drugs used in addictive disorders → N07BC Drugs used in opioid dependence
Discover more medicines within N07BC04

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
LUCEMYRA Film-coated tablet FDA, National Drug Code (US) MPI, US: SPL/PLR

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 31036-80-3
DrugBank Drug: DB04948
PubChem Compound: 30668
RxNorm Ingredient: 28863
SNOMED-CT Concept: 395989000
Lofexidine (substance)
UNII Identifier: UI82K0T627
LOFEXIDINE

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