Losartan Other names: Losartan potassium

Chemical formula: C₂₂H₂₃ClN₆O  Molecular mass: 422.911 g/mol  PubChem compound: 3961

Therapeutic indications

Losartan is indicated for:

Essential hypertension

Population group: only adults (18 years old or older)

Treatment of essential hypertension in adults and in children and adolescents 6-18 years of age.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Chronic heart failure

Population group: only adults (18 years old or older)

Treatment of chronic heart failure in adult patients when treatment with Angiotensin-converting enzyme (ACE) inhibitors is not considered suitable due to incompatibility, especially cough, or contraindication. Patients with heart failure who have been stabilised with an ACE inhibitor should not be switched to losartan. The patients should have a left ventricular ejection fraction ≤40% and should be clinically stable and on an established treatment regimen for chronic heart failure.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Renal disease with hypertension and type 2 diabetes mellitus

Population group: only adults (18 years old or older)

Treatment of renal disease in adult patients with hypertension and type 2 diabetes mellitus with proteinuria ≥0.5 g/day as part of an antihypertensive treatment.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Reduction in the risk of stroke in hypertensive patients with left-ventricular hypertrophy

Population group: only adults (18 years old or older)

Reduction in the risk of stroke in hypertensive patients with left-ventricular hypertrophy documented by ECG.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Essential hypertension

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Treatment of essential hypertension in adults and in children and adolescents 6-18 years of age.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Losartan is contraindicated in the following cases:

Pregnancy

Pregnancy

Aliskiren in diabetes mellitus or renal impairment (GFR <60 ml/min/1.73 m²)

Aliskiren and additionally at least one of
Diabetes mellitus



Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Severe hepatic impairment

Hepatic failure stage IV

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