Lurbinectedin
Chemical formula: C₄₁H₄₄N₄O₁₀S Molecular mass: 784.88 g/mol PubChem compound: 57327016
Active ingredient description
Lurbinectedin inhibits the oncogenic transcription process through (i) its binding to CG-rich sequences of DNA, located within promoters of protein-coding genes; (ii) the eviction of oncogenic transcription factors from their binding sites; and (iii) the stalling of elongating RNA polymerase II and its specific degradation by the ubiquitin/proteasome machinery with all these processes leading to subsequent cell cycle arrest and tumour cell apoptosis.
Medicine classification
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC Group | Classification | |
|---|---|---|
| L01XX69 | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01X Other antineoplastic agents → L01XX Other antineoplastic agents | |
Product monographs
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Document | Type | Information Source | |
|---|---|---|---|
| ZEPZELCA Powder for concentrate for solution for infusion | MPI, EU: SmPC | European Medicines Agency (EU) | |
| ZEPZELCA Powder for solution for injection | MPI, US: SPL/PLR | FDA, National Drug Code (US) |
Medicines
Lurbinectedin is an active ingredient of these brands:
Ecuador (EC)Israel (IL)Lithuania (LT)United States (US)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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