Chemical formula: C₇H₇NO₃ Molecular mass: 153.135 g/mol PubChem compound: 4075
Mesalazine is an aminosalicylate. The mechanism of action of mesalazine is not fully understood, but appears to have a topical anti-inflammatory effect on the colonic epithelial cells. Mucosal production of arachidonic acid metabolites, both through the cyclooxygenase and lipoxygenase pathways, is increased in patients with chronic inflammatory bowel disease, and it is possible that mesalazine diminishes inflammation by blocking cyclooxygenase and inhibiting prostaglandin production in the colon.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
ATC code | Group title | Classification |
---|---|---|
A07EC02 | Mesalazine | A Alimentary tract and metabolism → A07 Antidiarrheals, intestinal antiinflammatory/antiinfective agents → A07E Intestinal antiinflammatory agents → A07EC Aminosalicylic acid and similar agents |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
Title | Information Source | Document Type | |
---|---|---|---|
MEZAVANT XL Gastro-resistant, prolonged release tablets | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
ASACOLON Suppository | Health Products Regulatory Authority (IE) | MPI, EU: SmPC | |
ROWASA Rectal suspension | FDA, National Drug Code (US) | MPI, US: SPL/Old | |
PENTASA Suppository | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
ASACOLON Gastro-resistant tablet | Health Products Regulatory Authority (IE) | MPI, EU: SmPC | |
PENTASA Prolonged release granules | Health Products Regulatory Authority (IE) | MPI, EU: SmPC |
Mesalazine is an active ingredient of these brands:
Albania (AL)Brazil (BR)Nigeria (NG)Romania (RO)Turkey (TR)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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