Mesalazine Other names: Mesalamine Mesalazine 5-aminosalicylic acid 5-ASA

Chemical formula: C₇H₇NO₃  Molecular mass: 153.135 g/mol  PubChem compound: 4075

Active ingredient description

Mesalazine is an aminosalicylate. The mechanism of action of mesalazine is not fully understood, but appears to have a topical anti-inflammatory effect on the colonic epithelial cells. Mucosal production of arachidonic acid metabolites, both through the cyclooxygenase and lipoxygenase pathways, is increased in patients with chronic inflammatory bowel disease, and it is possible that mesalazine diminishes inflammation by blocking cyclooxygenase and inhibiting prostaglandin production in the colon.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
A07EC02 Mesalazine A Alimentary tract and metabolism → A07 Antidiarrheals, intestinal antiinflammatory/antiinfective agents → A07E Intestinal antiinflammatory agents → A07EC Aminosalicylic acid and similar agents
Discover more medicines within A07EC02

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
MEZAVANT XL Gastro-resistant, prolonged release tablets Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
ASACOLON Suppository Health Products Regulatory Authority (IE) MPI, EU: SmPC
ROWASA Rectal suspension FDA, National Drug Code (US) MPI, US: SPL/Old
PENTASA Suppository Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
ASACOLON Gastro-resistant tablet Health Products Regulatory Authority (IE) MPI, EU: SmPC
PENTASA Prolonged release granules Health Products Regulatory Authority (IE) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 89-57-6
DrugBank Drug: DB00244
KEGG Drug: D00377
PubChem Compound: 4075
RxNorm Ingredient: 52582
SNOMED-CT Concept: 387501005
Mesalazine (substance)
UNII Identifier: 4Q81I59GXC
MESALAMINE

Medicines

Mesalazine is an active ingredient of these brands:

Albania (AL)

Croatia (HR)

Finland (FI)

France (FR)

Hong Kong (HK)

Israel (IL)

Japan (JP)

New Zealand (NZ)

Nigeria (NG)

Singapore (SG)

Tunisia (TN)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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