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ATC Group: A07EC Aminosalicylic acid and similar agents

Anatomical Therapeutic Chemical Classification System

Hierarchical Position

Level
Code
Title
1
A
Alimentary tract and metabolism
2
A07
Antidiarrheals, intestinal antiinflammatory/antiinfective agents
3
A07E
Intestinal antiinflammatory agents
4
A07EC
Aminosalicylic acid and similar agents

Contents

Code
Title
A07EC01
Sulfasalazine
A07EC02
Mesalazine
A07EC03
Olsalazine
A07EC04
Balsalazide

Active Ingredients

Chemical substance
Description
Balsalazide

Balsalazide consists of mesalazine linked to a carrier molecule (4-aminobenzoyl-ß-alanine) via an azo bond. Bacterial azo-reduction releases mesalazine as an active metabolite in the colon. Mesalazine is an intestinal anti-inflammatory agent acting locally on the colonic mucosa. Its precise mechanism of action is unknown.

Mesalazine

Mesalazine is an aminosalicylate. The mechanism of action of mesalazine is not fully understood, but appears to have a topical anti-inflammatory effect on the colonic epithelial cells. Mucosal production of arachidonic acid metabolites, both through the cyclooxygenase and lipoxygenase pathways, is increased in patients with chronic inflammatory bowel disease, and it is possible that mesalazine diminishes inflammation by blocking cyclooxygenase and inhibiting prostaglandin production in the colon.

Olsalazine

Olsalazine is bioconverted to 5-aminosalicylic acid (5-ASA), which has anti-inflammatory activity in ulcerative colitis. The conversion of olsalazine to mesalamine (5-ASA) in the colon is similar to that of sulfasalazine, which is converted into sulfapyridine and mesalamine. The mechanism of action of mesalamine (and sulfasalazine) is unknown, but appears to be topical rather than systemic.

Sulfasalazine

Therapeutic benefit of sulfasalazine appears to be due to a local action of the sulfasalazine and its split product 5-aminosalicylic acid on the mucous membrane and deeper colonic structures.

Monographs

Monograph
Type
Country
COLAZIDE Capsule, hard
MPI, EU: SmPC
UK
DIPENTUM Capsule
MPI, US: SPL/Old
US
MEZAVANT XL Gastro-resistant, prolonged release tablets
MPI, EU: SmPC
UK
PENTASA Suppositories
MPI, EU: SmPC
UK
SALAZOPYRIN Suppository
MPI, EU: SmPC
UK