Leading the way to safer medication
 Crosscheck  Recommender

ATC Group: A07EC Aminosalicylic acid and similar agents

Anatomical Therapeutic Chemical Classification System

Translations

Language
Translation
  English
Aminosalicylic acid and similar agents

Hierarchical Position

Contents

Code
Title
A07EC01
A07EC02
A07EC03
A07EC04

Active Ingredients

Chemical substance
Description

Mesalazine is an aminosalicylate. The mechanism of action of mesalazine is not fully understood, but appears to have a topical anti-inflammatory effect on the colonic epithelial cells. Mucosal production of arachidonic acid metabolites, both through the cyclooxygenase and lipoxygenase pathways, is increased in patients with chronic inflammatory bowel disease, and it is possible that mesalazine diminishes inflammation by blocking cyclooxygenase and inhibiting prostaglandin production in the colon.

Olsalazine is bioconverted to 5-aminosalicylic acid (5-ASA), which has anti-inflammatory activity in ulcerative colitis. The conversion of olsalazine to mesalamine (5-ASA) in the colon is similar to that of sulfasalazine, which is converted into sulfapyridine and mesalamine. The mechanism of action of mesalamine (and sulfasalazine) is unknown, but appears to be topical rather than systemic.

Therapeutic benefit of sulfasalazine appears to be due to a local action of the sulfasalazine and its split product 5-aminosalicylic acid on the mucous membrane and deeper colonic structures.

Monographs

Monograph
Type
Country
MPI, US: SPL/Old
US
MPI, EU: SmPC
UK