Chemical formula: C₈H₁₈NO₂+ Molecular mass: 160.234 g/mol PubChem compound: 1993
Methacholine is a cholinergic agonist. Bronchial smooth muscle contains significant parasympathetic (cholinergic) innervation. Methacholine agonizes the muscarinic receptors which eventually induce bronchoconstriction.
After oral inhalation of methacholine, patients with asthma are more sensitive to methacholine-induced bronchoconstriction than are healthy subjects. This difference in response is the pharmacological basis for methacholine in the methacholine challenge test.
There are no metabolic and pharmacokinetic data available on methacholine chloride.
© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.
