Naltrexone

Chemical formula: C₂₀H₂₃NO₄ Molecular mass: 341.401 g/mol PubChem compound: 5360515

Therapeutic indications

Naltrexone is indicated for:

Opioid abstinence support

Population group: only adults (18 - 65 years old)

Opioid dependence

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Alcohol abstinence support

Population group: only adults (18 - 65 years old)

Naltrexone is used as part of a comprehensive programme of treatment against alcoholism to reduce the risk of relapse, as support treatment in abstinence and to reduce the craving for alcohol.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Naltrexone is contraindicated in the following cases:

Severe renal impairment

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Lactation

Severe or acute liver impairment

Hepatic failure stage IV

Acute hepatitis

Opioid-addicted patients

Opioid abuse

Opioids

Methadone

Positive result of the naloxone provocation test

Signs of opioid withdrawal on naloxone challenge test

Positive urine test for opioids

Urine opiate measurement

Central antihypertensives

Antiadrenergic agents, centrally acting

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