Naltrexone

Chemical formula: C₂₀H₂₃NO₄  Molecular mass: 341.401 g/mol  PubChem compound: 5360515

Active ingredient description

Naltrexone is an orally used, long acting specific opioid antagonist. Naltrexone binds competitively to receptors which are located in the central and peripheral nervous system and hence blocks the access for exogenously administered opioids.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
N07BB04 Naltrexone N Nervous system → N07 Other nervous system drugs → N07B Drugs used in addictive disorders → N07BB Drugs used in alcohol dependence
Discover more medicines within N07BB04

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
ADEPEND Film-coated tablet Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

3D molecular structure

3D representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 16590-41-3
CAS Substance: 16676-29-2
DrugBank Drug: DB00704
KEGG Drug: D05113
PubChem Compound: 5360515
RxNorm Ingredient: 7243
SNOMED-CT Concept: 373546002
Naltrexone (substance)
UNII Identifier: 5S6W795CQM
NALTREXONE

Medicines

Naltrexone is an active ingredient of these brands:

United States (US)

  • (combination) CONTRAVE as NALTREXONE HYDROCHLORIDE

Austria (AT)

  • DEPENDEX as NALTREXONE HYDROCHLORIDE
  • ETHYLEX as NALTREXONE HYDROCHLORIDE
  • NALTREXIN as NALTREXONE HYDROCHLORIDE

  • (combination) MYSIMBA as NALTREXONE HYDROCHLORIDE

Brazil (BR)

Canada (CA)

  • REVIA as NALTREXONE HYDROCHLORIDE

  • (combination) CONTRAVE as NALTREXONE HYDROCHLORIDE

Croatia (HR)

  • ADEPEND as NALTREXONE HYDROCHLORIDE

  • (combination) MYSIMBA as NALTREXONE HYDROCHLORIDE

Cyprus (CY)

  • ABERNIL as NALTREXONE HYDROCHLORIDE

  • (combination) MYSIMBA as NALTREXONE HYDROCHLORIDE

Ecuador (EC)

  • (combination) CONTRAVE as NALTREXONE HYDROCHLORIDE
  • (combination) NALTREVA as NALTREXONE HYDROCHLORIDE

Estonia (EE)

  • ADEPEND as NALTREXONE HYDROCHLORIDE
  • NODICT as NALTREXONE HYDROCHLORIDE

  • (combination) MYSIMBA as NALTREXONE HYDROCHLORIDE

Finland (FI)

  • (combination) MYSIMBA as NALTREXONE HYDROCHLORIDE

Hong Kong (HK)

  • NALOREX as NALTREXONE HYDROCHLORIDE

  • (combination) CONTRAVE as NALTREXONE HYDROCHLORIDE

Ireland (IE)

  • ETHYLEX as NALTREXONE HYDROCHLORIDE

  • (combination) MYSIMBA as NALTREXONE HYDROCHLORIDE

Italy (IT)

  • NALOREX as NALTREXONE HYDROCHLORIDE

  • (combination) MYSIMBA as NALTREXONE HYDROCHLORIDE

Lithuania (LT)

  • ADEPEND as NALTREXONE HYDROCHLORIDE

  • (combination) MYSIMBA as NALTREXONE HYDROCHLORIDE

Malta (MT)

Mexico (MX)

  • ARROP as NALTREXONE HYDROCHLORIDE

Netherlands (NL)

  • (combination) MYSIMBA as NALTREXONE HYDROCHLORIDE

New Zealand (NZ)

Poland (PL)

  • ADEPEND as NALTREXONE HYDROCHLORIDE
  • NALTEX as NALTREXONE HYDROCHLORIDE

  • (combination) MYSIMBA as NALTREXONE HYDROCHLORIDE

Romania (RO)

  • (combination) MYSIMBA as NALTREXONE HYDROCHLORIDE

Singapore (SG)

  • NARPAN as NALTREXONE HYDROCHLORIDE

South Africa (ZA)

  • ALTREX as NALTREXONE HYDROCHLORIDE
  • NALTIMA as NALTREXONE HYDROCHLORIDE

Spain (ES)

  • TRANALEX as NALTREXONE HYDROCHLORIDE

  • (combination) MYSIMBA as NALTREXONE HYDROCHLORIDE

Turkey (TR)

  • ETHYLEX as NALTREXONE HYDROCHLORIDE
  • NOKREV as NALTREXONE HYDROCHLORIDE

United Kingdom (UK)

  • ADEPEND as NALTREXONE HYDROCHLORIDE

  • (combination) MYSIMBA as NALTREXONE HYDROCHLORIDE

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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