Chemical formula: C₂₃H₃₂F₃N₅O₄ Molecular mass: 499.535 g/mol
Nirmatrelvir interacts in the following cases:
Coadministration of multiple oral 300 mg doses of carbamazepine decreased PF-07321332 AUCinf and Cmax. The ratios of the adjusted geometric means for PF-07321332 AUCinf and Cmax (90% CI) were 44.50% (90% CI: 33.77%, 58.65%) and 56.82% (90% CI: 47.04%, 68.62%), respectively, following PF-07321332/ritonavir 300 mg/100 mg coadministration with multiple oral doses of carbamazepine compared to PF-07321332/ritonavir administered alone.
Coadministration of multiple oral 200 mg doses of itraconazole increased PF-07321332 AUCtau and Cmax. The ratios of the adjusted geometric means (90% CI) for PF-07321332 AUCtau and Cmax were 138.82% (129.25%, 149.11%) and 118.57% (112.50%, 124.97%), respectively, when PF-07321332/ritonavir was coadministered with multiple doses of itraconazole as compared to PF-07321332/ritonavir administered alone.
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