Ofloxacin

Chemical formula: C₁₈H₂₀FN₃O₄  Molecular mass: 361.368 g/mol  PubChem compound: 4583

Therapeutic indications

Ofloxacin is indicated for:

Acute exacerbation of chronic bronchitis, community acquired pneumonia

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

at least one of
at least one of
Acute exacerbation of chronic bronchitis
Community acquired pneumonia
and additionally at least one of
Ofloxacin susceptible species
Ofloxacin susceptible species for which acquired resistance may be a problem

Woolsorters' disease
Acute streptococcal bronchitis
Streptococcal pneumonia
Acute bronchitis caused by Haemophilus influenzae
Haemophilus influenzae pneumonia
Pneumonic plague
Acute chlamydial bronchitis
Mycoplasma pneumonia

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Complicated skin and soft tissue infections

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

at least one of
at least one of
Soft tissue infection and additionally at least one of
Ofloxacin susceptible species
Ofloxacin susceptible species for which acquired resistance may be a problem

Cutaneous anthrax

Corynebacterial mastitis
Diphtheritic myocarditis
Polyneuropathy in diphtheria
Trichomycosis axillaris
Trichomycosis pubis
Pitted keratolysis
Streptococcal cellulitis
Streptococcal mastitis
Streptococcal skin disorder
† Salmonella infection with skin involvement
Bubonic plague
Cellulocutaneous plague
Chlamydia infection of skin

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Urinary tract infectious disease

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

at least one of
Urinary tract infectious disease and additionally at least one of
Ofloxacin susceptible species
Ofloxacin susceptible species for which acquired resistance may be a problem

Diphtheritic cystitis
Genitourinary chlamydia infection

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Pyelonephritis

Population group: only adults (18 years old or older)

Pyelonephritis and additionally at least one of
Ofloxacin susceptible species
Ofloxacin susceptible species for which acquired resistance may be a problem

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Prostatitis

Population group: men, only adults (18 years old or older)

Prostatitis and additionally at least one of
Ofloxacin susceptible species
Ofloxacin susceptible species for which acquired resistance may be a problem

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Orchitis and epididymitis

Population group: men, only adults (18 years old or older)

Orchitis and epididymitis and additionally at least one of
Ofloxacin susceptible species
Ofloxacin susceptible species for which acquired resistance may be a problem

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Infectious disease of abdomen

Population group: only adults (18 years old or older)

Infectious disease of abdomen and additionally at least one of
Ofloxacin susceptible species
Ofloxacin susceptible species for which acquired resistance may be a problem

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Bacterial conjunctivitis, bacterial keratitis, infective uveitis

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Ofloxacin is indicated for the topical treatment of external ocular infections (such as conjunctivitis and keratoconjunctivitis) in adults and children caused by ofloxacin – sensitive organisms. Safety and efficacy in the treatment of ophthalmia neonatorum has not been established.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Gonococcal urethritis, gonococcal cervicitis

Population group: only adults (18 years old or older)

at least one of
Gonococcal urethritis
Gonococcal cervicitis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Ofloxacin is contraindicated in the following cases:

Pregnancy

Pregnancy

Lactation

Lactation

G6PD deficiency

Deficiency of glucose-6-phosphate dehydrogenase

History of epilepsy, epilepsy

at least one of
H/O: epilepsy
Epilepsy

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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