Chemical formula: C₈H₁₂N₂ Molecular mass: 136.194 g/mol PubChem compound: 3675
Phenelzine is an irreversible non-selective inhibitor of monoamine oxidase. Although the exact mechanism of action has not been determined, it appears that the irreversible, nonselective inhibition of MAO by phenelzine relieves depressive symptoms by causing an increase in the levels of serotonin, norepinephrine, and dopamine in the neuron. Phenelzine is used for the treatment of major depressive disorder. Has also been used with some success in the management of bulimia nervosa.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| N06AF03 | Phenelzine | N Nervous system → N06 Psychoanaleptics → N06A Antidepressants → N06AF Monoamine oxidase inhibitors, non-selective |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| NARDIL Film coated tablet | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Phenelzine is an active ingredient of these brands:
United States (US)
Australia (AU)
Canada (CA)
Estonia (EE)
Netherlands (NL)
New Zealand (NZ)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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