Phentolamine

Chemical formula: C₁₇H₁₉N₃O  Molecular mass: 281.352 g/mol  PubChem compound: 5775

Active ingredient description

Phentolamine is a competitive non-selective α1- and α2-adrenergic receptor blocker of relatively short duration of action. It causes vasodilatation and a fall in blood pressure resulting from the blockade of both post-junctional vascular α1- and α2-adrenoceptors. It also antagonises the vasoconstrictor response to noradrenaline and adrenaline infusions.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
C04AB01 Phentolamine C Cardiovascular system → C04 Peripheral vasodilators → C04A Peripheral vasodilators → C04AB Imidazoline derivatives
Discover more medicines within C04AB01
V03AB36 Phentolamine V Various → V03 All other therapeutic products → V03A All other therapeutic products → V03AB Antidotes
Discover more medicines within V03AB36

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
ORAVERSE Solution for injection FDA, National Drug Code (US) MPI, US: SPL/PLR

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 50-60-2
CAS Substance: 65-28-1
DrugBank Drug: DB00692
PubChem Compound: 5775
RxNorm Ingredient: 8153
SNOMED-CT Concept: 372863003
Phentolamine (substance)
UNII Identifier: Z468598HBV
PHENTOLAMINE

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