Chemical formula: C₂₂H₂₂O₈ Molecular mass: 414.405 g/mol PubChem compound: 10607
Podophyllotoxin is a metaphase inhibitor in dividing cells binding to at least one binding site on tubulin. Binding prevents tubulin polymerisation required for microtubule assembly. At higher concentrations, podophyllotoxin also inhibits nucleoside transport through the cell membrane.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| D06BB04 | Podophyllotoxin | D Dermatologicals → D06 Antibiotics and chemotherapeutics for dermatological use → D06B Chemotherapeutics for topical use → D06BB Antivirals |
| L01CB | Podophyllotoxin derivatives | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01C Plant alkaloids and other natural products |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| WARTICON Topical cream | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Podophyllotoxin is an active ingredient of these brands:
United States (US)Canada (CA)Ecuador (EC)France (FR)Hong Kong (HK)Israel (IL)Lithuania (LT)Malta (MT)New Zealand (NZ)Romania (RO)South Africa (ZA)Spain (ES)Turkey (TR)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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