Prilocaine

Chemical formula: C₁₃H₂₀N₂O Molecular mass: 220.311 g/mol PubChem compound: 4906

Active ingredient description

Prilocaine is a toluidine derivative and intermediate-acting amino amide with local anesthetic property. Prilocaine binds to the intracellular surface of sodium channels which blocks the subsequent influx of sodium into the cell. Action potential propagation and never function is, therefore, prevented. This block is reversible and when the drug diffuses away from the cell, sodium channel function is restored and nerve propagation returns.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code	Group title	Classification
N01BB04	Prilocaine	N Nervous system → N01 Anesthetics → N01B Anesthetics, local → N01BB Amides
Discover more medicines within N01BB04

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title	Information Source	Document Type
PRILOTEKAL Solution for injection	Medicines & Healthcare Products Regulatory Agency (GB)	MPI, EU: SmPC
CITANEST PLAIN Solution for injection	FDA, National Drug Code (US)	MPI, US: SPL/Old

Medicines

Prilocaine is an active ingredient of these brands:

United States (US)

CITANEST as PRILOCAINE HYDROCHLORIDE
(combination) CITANEST FORTE as PRILOCAINE HYDROCHLORIDE
(combination) ORAQIX

Austria (AT)

TAKIPRIL as PRILOCAINE HYDROCHLORIDE
(combination) EMLA
(combination) FORTACIN
(combination) SENSTEND

Brazil (BR)

(combination) CITANEST OCTAPRESSIN as PRILOCAINE HYDROCHLORIDE
(combination) CITOCAINA as PRILOCAINE HYDROCHLORIDE
(combination) EMLA
(combination) PRILONEST as PRILOCAINE HYDROCHLORIDE

Canada (CA)

(combination) EMLA
(combination) ORAQIX

Croatia (HR)

(combination) FORTACIN

Cyprus (CY)

(combination) EMLA
(combination) XYLOCREAM

Ecuador (EC)

TAKIPRIL as PRILOCAINE HYDROCHLORIDE
(combination) ANESTECIN
(combination) DOCAINEX

Estonia (EE)

(combination) EMLA
(combination) FORTACIN
(combination) LPKAIN
(combination) NULBIA
(combination) ORAQIX
(combination) SENSTEND
(combination) XYLOCREAM

Finland (FI)

TAKIPRIL as PRILOCAINE HYDROCHLORIDE
(combination) CITANEST OCTAPRESSIN as PRILOCAINE HYDROCHLORIDE
(combination) EMLA
(combination) ORAQIX
(combination) TAPIN

France (FR)

BARITEKAL as PRILOCAINE HYDROCHLORIDE
(combination) ANESDERM
(combination) EMLA
(combination) FORTACIN
(combination) ORAQIX

Hong Kong (HK)

(combination) EMLA
(combination) EMLO
(combination) ENCAIN
(combination) FORTACIN
(combination) LIDIPRINE
(combination) PRIDOPAN
(combination) PRILIDO
(combination) XYLOCREAM

Ireland (IE)

(combination) CITANEST OCTAPRESSIN as PRILOCAINE HYDROCHLORIDE
(combination) EMLA
(combination) FORTACIN
(combination) ORAQIX
(combination) SENSTEND

Israel (IL)

(combination) EMLA

Italy (IT)

(combination) FORTACIN

Japan (JP)

(combination) EMLA

Lithuania (LT)

(combination) FORTACIN
(combination) SENSTEND

Malta (MT)

CITANEST as PRILOCAINE HYDROCHLORIDE
(combination) CITANEST OCTAPRESSIN as PRILOCAINE HYDROCHLORIDE
(combination) EMLA
(combination) OPRALIX as PRILOCAINE HYDROCHLORIDE

Mexico (MX)

(combination) EMLA

Netherlands (NL)

CITANEST as PRILOCAINE HYDROCHLORIDE
PRILOTEKAL as PRILOCAINE HYDROCHLORIDE
(combination) CITANEST OCTAPRESSIN as PRILOCAINE HYDROCHLORIDE
(combination) EMLA

New Zealand (NZ)

CITANEST as PRILOCAINE HYDROCHLORIDE
(combination) CITANEST OCTAPRESSIN as PRILOCAINE HYDROCHLORIDE
(combination) EMLA
(combination) NUMIT
(combination) ORAQIX

Poland (PL)

PRILOTEKAL as PRILOCAINE HYDROCHLORIDE
(combination) ANESDERM
(combination) EMLA
(combination) FORTACIN
(combination) MOTTI
(combination) SENSTEND

Romania (RO)

(combination) FORTACIN
(combination) ROMLA

Singapore (SG)

(combination) CITANEST OCTAPRESSIN as PRILOCAINE HYDROCHLORIDE
(combination) EMLA
(combination) RACSER

South Africa (ZA)

(combination) EMLA
(combination) TOPLA

Spain (ES)

TAKIPRIL as PRILOCAINE HYDROCHLORIDE
(combination) ANAMAP
(combination) ANESTDERMA
(combination) ANESTEAL
(combination) ANESTOPIC
(combination) EMLA
(combination) FORTACIN
(combination) ORAQIX

Tunisia (TN)

(combination) EMLA
(combination) PRILIA

Turkey (TR)

CITANEST as PRILOCAINE HYDROCHLORIDE
PRICAIN as PRILOCAINE HYDROCHLORIDE
PRICALEST as PRILOCAINE HYDROCHLORIDE
PRILOSEL as PRILOCAINE HYDROCHLORIDE
PRINEST as PRILOCAINE HYDROCHLORIDE
(combination) DICAIN
(combination) EMLA
(combination) EMLONG
(combination) JETEX
(combination) LIDORIN
(combination) LOCPYNOL as PRILOCAINE HYDROCHLORIDE
(combination) LOKARIL as PRILOCAINE HYDROCHLORIDE
(combination) LPKAIN
(combination) PELONG
(combination) PROTECTOL

United Kingdom (UK)

CITANEST as PRILOCAINE HYDROCHLORIDE
PRILOTEKAL as PRILOCAINE HYDROCHLORIDE
(combination) DENELA
(combination) EMLA
(combination) FORTACIN
(combination) NULBIA
(combination) ORAQIX

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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