Chemical formula: C₁₁H₁₆ClN₅ Molecular mass: 253.731 g/mol PubChem compound: 4923
Proguanil is an antimalarial drug and dihydrofolate reductase inhibitor. It acts like the other antifolate antimalarials by interfering with the folic-folinic acid systems and thus exerts its effect mainly at the time the nucleus is dividing. Proguanil is effective against the exoerythrocytic forms of some strains of plasmodium falciparum but it has little or no activity against the exoerythrocytic forms of p. Vivax.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| P01BB01 | Proguanil | P Antiparasitic products, insecticides and repellents → P01 Antiprotozoals → P01B Antimalarials → P01BB Biguanides |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| PALUDRINE Tablet | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Proguanil is an active ingredient of these brands:
United States (US)
Australia (AU)
Austria (AT)
Canada (CA)
Estonia (EE)
Finland (FI)
France (FR)Ireland (IE)
Israel (IL)
Japan (JP)
Lithuania (LT)
Malta (MT)
Netherlands (NL)New Zealand (NZ)
Nigeria (NG)Poland (PL)Singapore (SG)
South Africa (ZA)Spain (ES)United Kingdom (UK)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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