Reteplase

Active ingredient description

Reteplase is a recombinant plasminogen activator that catalyzes the cleavage of endogenous plasminogen to generate plasmin. This plasminogenolysis occurs preferentially in the presence of fibrin. Plasmin in turn degrades fibrin, which is the main component of the matrix of thrombi, thereby exerting its thrombolytic action.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
B01AD07 Reteplase B Blood and blood forming organs → B01 Antithrombotic agents → B01A Antithrombotic agents → B01AD Enzymes
Discover more medicines within B01AD07

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
RAPILYSIN Powder and solvent for solution for injection European Medicines Agency (EU) MPI, EU: SmPC

3D molecular structure

3D representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 133652-38-7
DrugBank Drug: DB00015
RxNorm Ingredient: 76895
SNOMED-CT Concept: 386957002
Reteplase (substance)
UNII Identifier: DQA630RIE9
RETEPLASE

Medicines

Reteplase is an active ingredient of these brands:

Australia (AU)

Austria (AT)

Croatia (HR)

Cyprus (CY)

Estonia (EE)

Finland (FI)

France (FR)

Hong Kong (HK)

Ireland (IE)

Italy (IT)

Lithuania (LT)

New Zealand (NZ)

Poland (PL)

Turkey (TR)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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