Rosiglitazone

Active ingredient description

Rosiglitazone is a selective agonist at the PPARγ (peroxisomal proliferator activated receptor gamma) nuclear receptor and is a member of the thiazolidinedione class of anti-diabetic agents. It reduces glycaemia by reducing insulin resistance at adipose tissue, skeletal muscle and liver.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
A10BG02
Rosiglitazone
A Alimentary tract and metabolism → A10 Drugs used in diabetes → A10B Blood glucose lowering drugs, excl. insulins → A10BG Thiazolidinediones
Discover more medicines within A10BG02

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
AVANDIA Film-coated tablet
Structured Product Labeling (SPL/PLR)
US

Medicines

Rosiglitazone is the active ingredient of these drugs:

Drug
Countries
AVANDIA

Lithuania United States

Rosiglitazone is also found within below combination drugs:

AVANDAMET , AVANDARYL

Structural formula

Graphic representation of the active ingredient's molecular structure

Chemical formula: C₁₈H₁₉N₃O₃S
Molecular mass: 357.427 g/mol

External identifiers

CAS Substance: 122320-73-4
DrugBank Drug: DB00412
KEGG Drug: D00596
PubChem Compound: 77999
RxNorm Ingredient: 84108
SNOMED-CT Concept: 395869000
Rosiglitazone (substance)
UNII Identifier: 05V02F2KDG
ROSIGLITAZONE
 
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