Leading the way to safer medication
 Crosscheck  Recommender

ATC Group: A10BG Thiazolidinediones

Anatomical Therapeutic Chemical Classification System

Hierarchical Position

Level
Code
Title
1
A
Alimentary tract and metabolism
2
A10
Drugs used in diabetes
3
A10B
Blood glucose lowering drugs, excl. insulins
4
A10BG
Thiazolidinediones

Contents

Code
Title
A10BG01
Troglitazone
A10BG02
Rosiglitazone
A10BG03
Pioglitazone
A10BG04
Lobeglitazone

Active Ingredients

Chemical substance
Description
Pioglitazone

Pioglitazone effects may be mediated by a reduction of insulin resistance. Pioglitazone appears to act via activation of specific nuclear receptors (peroxisome proliferator activated receptor gamma) leading to increased insulin sensitivity of liver, fat and skeletal muscle cells in animals. Treatment with pioglitazone has been shown to reduce hepatic glucose output and to increase peripheral glucose disposal in the case of insulin resistance.

Rosiglitazone

Rosiglitazone is a selective agonist at the PPARĪ³ (peroxisomal proliferator activated receptor gamma) nuclear receptor and is a member of the thiazolidinedione class of anti-diabetic agents. It reduces glycaemia by reducing insulin resistance at adipose tissue, skeletal muscle and liver.

Monographs

Monograph
Type
Country
ACTOS Tablet
MPI, US: SPL/PLR
US
AVANDIA Film-coated tablet
MPI, US: SPL/PLR
US
PIOGLITAZONE ACCORD Tablet
MPI, EU: SmPC
UK