Chemical formula: C₂₂H₂₈FN₃O₆S Molecular mass: 481.538 g/mol PubChem compound: 446157
Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase. Rosuvastatin increases the number of hepatic LDL receptors on the cell-surface, enhancing uptake and catabolism of LDL and it inhibits the hepatic synthesis of VLDL, thereby reducing the total number of VLDL and LDL particles.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C10AA07 | Rosuvastatin | C Cardiovascular system → C10 Lipid modifying agents → C10A Lipid modifying agents, plain → C10AA HMG CoA reductase inhibitors |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| CRESTOR Film-coated tablet | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Rosuvastatin is an active ingredient of these brands:
United States (US)
Australia (AU)Austria (AT)
Brazil (BR)
Canada (CA)
Croatia (HR)
Cyprus (CY)Ecuador (EC)
Estonia (EE)
Finland (FI)
France (FR)Germany (DE)Hong Kong (HK)
Ireland (IE)Italy (IT)
Lithuania (LT)
Malta (MT)
Nigeria (NG)
Poland (PL)
Romania (RO)
Singapore (SG)South Africa (ZA)
Spain (ES)
Tunisia (TN)Turkey (TR)
United Kingdom (UK)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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