Silymarin Other names: Silibinin Silybin

Chemical formula: C₂₅H₂₂O₁₀  Molecular mass: 482.441 g/mol  PubChem compound: 31553

Active ingredient description

Silymarin is a plant-derived flavonoid from the plant Silybum marianum. The main component of the silymarin complex is silybin, which is a mixture of two diastereomers A and B in approximately 1:1 proportion. The drug possess hepatoprotective and antioxidant activity. The hepatoprotective effect is due to stimulation of synthesis of structural and functional proteins and phospholipids, as well as acceleration of the regeneration of hepatocytes. Antioxidant effect is determined by interaction of bioflavones with free radicals in the liver and its detoxication. In such manner the process of peroxidation of the lipids is interrupted and further liver destruction is prevented.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
A05BA03 Silymarin A Alimentary tract and metabolism → A05 Bile and liver therapy → A05B Liver therapy, lipotropics → A05BA Liver therapy
Discover more medicines within A05BA03

External identifiers

CAS Substance: 22888-70-6
DrugBank Drug: DB09298
KEGG Drug: D08515
PubChem Compound: 31553
RxNorm Ingredient: 9794
UNII Identifier: 4RKY41TBTF


Silymarin is an active ingredient of these brands:

Brazil (BR)

Ecuador (EC)

Estonia (EE)

Hong Kong (HK)

Lithuania (LT)

Mexico (MX)

Nigeria (NG)

Poland (PL)

Romania (RO)

  • LAGOSA as Silybum marianum seed extract

South Africa (ZA)

Spain (ES)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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