Chemical formula: NaCl Molecular mass: 58.443 g/mol PubChem compound: 5234
Sodium chloride interacts in the following cases:
Corticoids/steroids and carbenoxolone, are associated with the retention of sodium and water (with oedema and hypertension).
The below listed drugs increase the vasopressin effect, leading to reduced renal electrolyte free water excretion and may increase the risk of hospital acquired hyponatraemia following inappropriately balanced treatment with i.v. fluids.
Drugs stimulating vasopressin release include: Chlorpropamide, clofibrate, carbamazepine, vincristine, selective serotonin reuptake inhibitors, 3.4-methylenedioxy-N-methamphetamine, ifosfamide, antipsychotics, narcotics
Drugs potentiating vasopressin action include: Chlorpropamide, NSAIDs, cyclophosphamide
Vasopressin analogues include: Desmopressin, oxytocin, terlipressin
Other medicinal products increasing the risk of hyponatraemia also include diuretics in general and antiepileptics such as oxcarbazepine.
Caution is advised in patients treated with lithium. Renal sodium and lithium clearance may be increased during administration of sodium chloride. Administration of sodium chloride may result in decreased lithium levels.
There are no adequate data from the use of sodium chloride in pregnant women. The physician should carefully consider the potential risks and benefits for each specific patient before administering sodium chloride.
Sodium chloride should be administrated with special caution for pregnant women during labour particularly as to serum-sodium if administered in combination with oxytocin.
Caution is advised with patients with pre-eclampsia.
When a medicinal product is added, the nature of the drug and its use during pregnancy has to be considered separately.
There are no adequate data from the use of sodium chloride in lactating women. The physician should carefully consider the potential risks and benefits for each specific patient before administering sodium chloride.
Caution is advised with patients with pre-eclampsia.
When a medicinal product is added, the nature of the drug and its use during lactation has to be considered separately.
No studies have been conducted on the influence of sodium chloride on the ability to operate an automobile or other heavy machinery.
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