Sodium fluoride

Chemical formula: NaF  Molecular mass: 41.988 g/mol  PubChem compound: 5235

Active ingredient description

Sodium fluoride is indicated for the prevention of dental caries in adolescents and adults, particularly amongst patients at risk from multiple caries (coronal and/or root caries). The primary mode of the caries preventative action of fluoride is post-eruptive, i.e topical action. Systemic fluoride supplements are believed also to act mainly topically (i.e during ingestion, via saliva).

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
A01AA01 Sodium fluoride A Alimentary tract and metabolism → A01 Stomatological preparations → A01A Stomatological preparations → A01AA Caries prophylactic agents
Discover more medicines within A01AA01
A12CD01 Sodium fluoride A Alimentary tract and metabolism → A12 Mineral supplements → A12C Other mineral supplements → A12CD Fluoride
Discover more medicines within A12CD01

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
FLUORIDE 5000 ppm Toothpaste Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 7681-49-4
DrugBank Drug: DB09325
PubChem Compound: 5235
RxNorm Ingredient: 9873
SNOMED-CT Concept: 375696005
Sodium fluoride 2% (product)
SNOMED-CT Concept: 6910009
Sodium fluoride (substance)
UNII Identifier: 8ZYQ1474W7


Sodium fluoride is an active ingredient of these brands:

Austria (AT)

Brazil (BR)

Croatia (HR)

Cyprus (CY)

Ecuador (EC)

Estonia (EE)

Finland (FI)

France (FR)

Germany (DE)

Hong Kong (HK)

Ireland (IE)

Japan (JP)

Lithuania (LT)

Malta (MT)

Netherlands (NL)

New Zealand (NZ)

Poland (PL)

Romania (RO)

Singapore (SG)

South Africa (ZA)

Spain (ES)

Tunisia (TN)

Turkey (TR)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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