Solifenacin

Chemical formula: C₂₃H₂₆N₂O₂  Molecular mass: 362.473 g/mol  PubChem compound: 154059

Therapeutic indications

Solifenacin is indicated for:

Neurogenic detrusor overactivity

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Neurogenic detrusor overactivity

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Overactive bladder

Population group: only adults (18 years old or older)

Solifenacin is indicated for symptomatic treatment of urge incontinence and/or increased urinary frequency and urgency as may occur in patients with overactive bladder (OAB) syndrome.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Solifenacin is contraindicated in the following cases:

Urinary retention

Retention of urine

Haemodialysis

Hemodialysis procedure

Toxic megacolon

† Toxic megacolon

Myasthenia gravis

Myasthenia gravis

Angle-closure glaucoma

Angle-closure glaucoma

Potent CYP3A4 inhibitor and severe renal impairment

Strong CYP3A4 inhibitors and additionally at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Severe hepatic impairment

Hepatic failure stage IV

Potent CYP3A4 inhibitors and moderate hepatic impairment

Strong CYP3A4 inhibitors and additionally Hepatic failure stage III

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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