Tacrolimus

Active ingredient description

Tacrolimus is a highly potent immunosuppressive agent. In particular, tacrolimus inhibits the formation of cytotoxic lymphocytes, which are mainly responsible for graft rejection. Tacrolimus suppresses T-cell activation and T-helper-cell dependent B-cell proliferation, as well as the formation of lymphokines (such as interleukins-2, -3, and γ-interferon) and the expression of the interleukin-2 receptor.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
Tacrolimus
D Dermatologicals → D11 Other dermatological preparations → D11A Other dermatological preparations → D11AH Agents for dermatitis, excluding corticosteroids
Discover more medicines within D11AH01
Tacrolimus
L Antineoplastic and immunomodulating agents → L04 Immunosuppressants → L04A Immunosuppressants → L04AD Calcineurin inhibitors
Discover more medicines within L04AD02

Medicines

Tacrolimus is the active ingredient of these drugs:

Drug
Countries

France Italy Spain United Kingdom

Austria Finland Netherlands

Australia Austria Canada Cyprus Finland

United States

Brazil

Italy

Spain

Poland

Italy Spain

Brazil

Austria Finland Lithuania Netherlands Poland

Poland

Austria Canada Finland France Ireland

South Africa

South Africa

Lithuania

Austria Finland France Ireland Lithuania

South Africa

Australia

Australia Austria Brazil Canada Cyprus

Netherlands

Austria Brazil Canada Cyprus Finland

Hong Kong

Austria Ireland Italy Lithuania Poland

Austria Italy Poland Spain

Brazil

Australia

Brazil

Hong Kong

Brazil Hong Kong

Austria France Italy Netherlands Spain

Brazil

Hong Kong

New Zealand

Product monographs

Medicine agencies around the world have authorized marketing of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
Summary of Product Characteristics (SPC)
UK
Summary of Product Characteristics (SPC)
UK
Summary of Product Characteristics (SPC)

Structural formula

Graphic representation of the active ingredient's molecular structure

Unique ingredient identifier (UNII)

WM0HAQ4WNM - TACROLIMUS

CAS registry number

104987-11-3 - tacrolimus

SNOMED-CT

386975001 - Tacrolimus (substance)