Tecovirimat

Chemical formula: C₁₉H₁₅F₃N₂O₃  Molecular mass: 376.335 g/mol  PubChem compound: 16124688

Active ingredient description

Tecovirimat is an antiviral drug against variola (smallpox) virus. Tecovirimat inhibits the activity of the orthopoxvirus VP37 protein, which is encoded by a highly conserved gene in all members of the orthopoxvirus genus. Tecovirimat blocks the interaction of VP37 with cellular Rab9 GTPase and TIP47, which prevents the formation of egress competent enveloped virions necessary for cell-to-cell and long-range dissemination of virus.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
J05AX24 J Antiinfectives for systemic use → J05 Antivirals for systemic use → J05A Direct acting antivirals → J05AX Other antivirals
Discover more medicines within J05AX24

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
TECOVIRIMAT SIGA Hard capsule European Medicines Agency (EU) MPI, EU: SmPC
TPOXX Capsule FDA, National Drug Code (US) MPI, US: SPL/PLR

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 869572-92-9
DrugBank Drug: DB12020
PubChem Compound: 16124688
RxNorm Ingredient: 2055104
SNOMED-CT Concept: 772991002
Tecovirimat (substance)
UNII Identifier: F925RR824R
TECOVIRIMAT

© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.