Chemical formula: C₂₉H₂₈N₆O₂ Molecular mass: 492.583 g/mol
Tepotinib is a reversible Type I adenosine triphosphate (ATP)-competitive small molecule inhibitor of MET. Tepotinib blocked MET phosphorylation and MET-dependent downstream signalling in a dose-dependent manner. Tepotinib demonstrated pronounced anti-tumour activity in tumours with oncogenic activation of MET, such as METex14 skipping alterations.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L01EX21 | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01E Protein kinase inhibitors → L01EX Other protein kinase inhibitors | |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| TEPMETKO Film-coated tablet | FDA, National Drug Code (US) | MPI, US: SPL/PLR | |
| TEPMETKO Film-coated tablet | European Medicines Agency (EU) | MPI, EU: SmPC |
Tepotinib is an active ingredient of these brands:
United States (US)
Austria (AT)
Brazil (BR)
Croatia (HR)
Estonia (EE)
Finland (FI)
Israel (IL)
Italy (IT)
Japan (JP)
Lithuania (LT)
Poland (PL)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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