Tibolone

Chemical formula: C₂₁H₂₈O₂  Molecular mass: 312.453 g/mol  PubChem compound: 444008

Therapeutic indications

Tibolone is indicated for:

Prevention of osteoporosis in postmenopausal women

Population group: women, only adults (18 years old or older)

Prevention of osteoporosis in postmenopausal women at high risk of future fractures who are intolerant of, or contraindicated for, other medicinal products approved for the prevention of osteoporosis.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Oestrogen deficiency in menopause

Population group: women, only adults (18 years old or older)

Treatment of oestrogen deficiency symptoms in postmenopausal women, more than one year after menopause.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Tibolone is contraindicated in the following cases:

Endometrial hyperplasia

Endometrial hyperplasia

Pregnancy

Pregnancy

Lactation

Lactation

Hypersensitivity to tibolone

Tibolone allergy

Porphyria

Porphyria

Liver disease

at least one of
Hepatopathy
H/O: liver disease

Arterial thromboembolic disease

Arterial thrombosis

Thrombophilic disorders

Thrombophilia

Venous thromboembolism

at least one of
Thromboembolism of vein
Venous thrombosis
Venous embolism
Pulmonary embolism

Untreated endometrial hyperplasia

Observations of vaginal bleeding

Endometrial cancer

Malignant neoplasm of uterus

Breast cancer

Malignant tumor of breast

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