Tibolone

Chemical formula: C₂₁H₂₈O₂  Molecular mass: 312.453 g/mol  PubChem compound: 444008

Active ingredient description

Tibolone is rapidly metabolised into three compounds, which all contribute to the pharmacodynamic profile of tibolone. Two of the metabolites (3α-OH-tibolone and 3β-OH-tibolone) have oestrogenic-like activities, whereas the third metabolite (4Δ-isomer of tibolone) has progestogenic and androgenic-like activities.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
G03CX01 Tibolone G Genito urinary system and sex hormones → G03 Sex hormones and modulators of the genital system → G03C Estrogens → G03CX Other estrogens
Discover more medicines within G03CX01

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
TIBOLONE Tablet Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 5630-53-5
DrugBank Drug: DB09070
KEGG Drug: D01639
PubChem Compound: 444008
RxNorm Ingredient: 38260
SNOMED-CT Concept: 395903002
Tibolone (substance)
UNII Identifier: FF9X0205V2
TIBOLONE

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