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ATC Group: G03C Estrogens

Anatomical Therapeutic Chemical Classification System

Hierarchical Position

Level
Code
Title
1
G
Genito urinary system and sex hormones
2
G03
Sex hormones and modulators of the genital system
3
G03C
Estrogens

Contents

Code
Title
G03CA
Natural and semisynthetic estrogens, plain
G03CB
Synthetic estrogens, plain
G03CC
Estrogens, combinations with other drugs
G03CX
Other estrogens

Active Ingredients

Chemical substance
Description
Diethylstilbestrol

Diethylstilbestrol is a synthetic nonsteroidal estrogen, that was widely used to prevent potential miscarriages by stimulating the synthsis of estrogen and progesterone in the placenta. It was also used for the treatment of symptoms arising during menopause and following ovariectomy and for senile vaginitis and vulvar dystrophy. Diethylstilbestrol was used as a postcoital emergency contraceptive (morning-after pill). It has also been used for the prevention of postpartum breast engorgement, for dysfuctional menstrual cycles and for the treatment of female hypogonadism. Diethylstilbestrol is now rarely used to treat prostate cancer and occacionally in postmenopausal women with breast cancer because of its side-effects.

Estradiol

Estradiol, is chemically and biologically identical to endogenous human estradiol. It substitutes for the loss of oestrogen production in menopausal women, and alleviates menopausal symptoms. Oestrogens prevent bone loss following menopause or ovariectomy.

Estriol
Estrogens
Estrogens, conjugated

The active ingredients of conjugated estrogens are primarily the sulfate esters of estrone, equilin sulfates, 17α-estradiol and 17β-estradiol. These substitute for the loss of estrogen production in menopausal women, and alleviate menopausal symptoms. Estrogens prevent bone loss following menopause or ovariectomy.

Estrone

Estrone is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. Estrone is a major mammalian estrogen. It is converted from androstenedione directly, or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion of adrostenedione.

17 alpha-Ethinylestradiol

Ethinylestradiol is chemically and biologically identical to endogenous human oestradiol. It substitutes for the loss of estrogen production in menopausal women, and alleviates menopausal symptoms. Estrogens prevent bone loss following menopause or ovariectomy.

Tibolone

Tibolone is rapidly metabolised into three compounds, which all contribute to the pharmacodynamic profile of tibolone. Two of the metabolites (3α-OH-tibolone and 3β-OH-tibolone) have oestrogenic-like activities, whereas the third metabolite (4Δ-isomer of tibolone) has progestogenic and androgenic-like activities.

Monographs

Monograph
Type
Country
CLIMARA Patch
MPI, US: SPL/PLR
US
DIVIGEL Gel
MPI, US: SPL/PLR
US
ESTRACE Cream
MPI, US: SPL/Old
US
ESTRACE Tablet
MPI, US: SPL/Old
US
ESTRADERM Transdermal patch
MPI, EU: SmPC
UK
ESTRADOT Transdermal patch
MPI, EU: SmPC
UK
ESTRAGYN Vaginal cream
MPI, CA: SPM
CA
ESTRING Vaginal delivery system
MPI, EU: SmPC
UK
ESTROGEL Gel
MPI, US: SPL/PLR
US
LENZETTO Transdermal spray, solution
MPI, EU: SmPC
UK
OVESTIN Vaginal cream
MPI, EU: SmPC
UK
PREMARIN Coated tablet
MPI, EU: SmPC
UK
PREMARIN Film-coated tablet
MPI, US: SPL/PLR
US
PREMARIN Powder for solution for injection
MPI, US: SPL/Old
US
PREMARIN Vaginal cream
MPI, US: SPL/PLR
US
PROGYNOVA 1mg Coated tablet
MPI, EU: SmPC
UK
PROGYNOVA 2mg Coated tablet
MPI, EU: SmPC
UK
PROGYNOVA Transdermal patch
MPI, EU: SmPC
UK
SANDRENA Gel
MPI, EU: SmPC
UK
TIBOLONE Tablet
MPI, EU: SmPC
UK
ZUMENON Film-coated tablet
MPI, EU: SmPC
UK