ATC Group: G03CC Estrogens, combinations with other drugs

Diethylstilbestrol is a synthetic nonsteroidal estrogen, that was widely used to prevent potential miscarriages by stimulating the synthsis of estrogen and progesterone in the placenta. It was also used for the treatment of symptoms arising during menopause and following ovariectomy and for senile vaginitis and vulvar dystrophy. Diethylstilbestrol was used as a postcoital emergency contraceptive (morning-after pill). It has also been used for the prevention of postpartum breast engorgement, for dysfuctional menstrual cycles and for the treatment of female hypogonadism. Diethylstilbestrol is now rarely used to treat prostate cancer and occacionally in postmenopausal women with breast cancer because of its side-effects.

Estriol is a steroid, a weak estrogen, specifically an agonist of the estrogen receptors ERα and ERβ. It is one of three major endogenous estrogens, the others being estradiol and estrone.

Estrone is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. Estrone is a major mammalian estrogen. It is converted from androstenedione directly, or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion of adrostenedione.