Chemical formula: Câ‚…Hâ‚…Nâ‚…S Molecular mass: 167.192 g/mol PubChem compound: 2723601
Tioguanine is a sulphydryl analogue of guanine and behaves as a purine antimetabolite. It is activated to its nucleotide, thioguanylic acid. Tioguanine metabolites inhibit de novo purine synthesis and purine nucleotide interconversions. Tioguanine is also incorporated into nucleic acids and DNA (deoxyribonucleic acid) incorporation is claimed to contribute to the agent’s cytotoxicity.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L01BB03 | Tioguanine | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01B Antimetabolites → L01BB Purine analogues |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| TIOGUANINE Tablet | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Tioguanine is an active ingredient of these brands:
United States (US)
Australia (AU)
Brazil (BR)
Canada (CA)
Estonia (EE)
France (FR)
Hong Kong (HK)
Ireland (IE)
Lithuania (LT)
New Zealand (NZ)
Poland (PL)
Romania (RO)
South Africa (ZA)
Turkey (TR)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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