Ulinastatin

Ulinastatin is a protease inhibitor extracted from human urine. Ulinastatin inhibits inflammatory markers: trypsin, pancreatic elastase, polymorphonuclear leukocyte elastase and the endotoxin-stimulated production of TNF alpha and interleukin 1, 8 and 6. It inhibits coagulation and fibrinolysis and promotes microperfusion. Thus, ulinastatin is an effective agent for immune modulation to prevent organ dysfunction and promote homeostasis.

• After intravenous injection of 300,000 I.U./10 ml into healthy man, its concentration in blood decreases linearly.
• The half life of ulinastatin is about 40 minutes.
• 6 hours after the administration, 24% of ulinastatin is discharged in urine.