Vorasidenib

Chemical formula: C₁₄H₁₃ClF₆N₆  Molecular mass: 414.079 g/mol  PubChem compound: 117817422

Active ingredient description

Vorasidenib is an inhibitor that targets the mutant IDH1 and IDH2 enzymes. In patients with astrocytoma or oligodendroglioma, IDH1 and IDH2 mutations lead to overproduction of the oncogenic metabolite 2-hydroxyglutarate (2-HG), resulting in impaired cellular differentiation contributing to oncogenesis. Inhibition of the IDH1- and IDH2-mutated proteins by vorasidenib inhibits the abnormal production of 2-HG leading to differentiation of malignant cells and a reduction in their proliferation.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC Group Classification
L01XM04 L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01X Other antineoplastic agents → L01XM Isocitrate dehydrogenase (IDH) inhibitors
Discover more medicines within L01XM04

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Document Type Information Source  
 VORANIGO Film-coated tablet MPI, EU: SmPC European Medicines Agency (EU)

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

DrugBank Drug: DB17097
KEGG Drug: D11834
PubChem Compound: 117817422
RxNorm Ingredient: 2690647
UNII Identifier: 789Q85GA8P
VORASIDENIB

Medicines

Vorasidenib is an active ingredient of these brands:

Austria (AT)

Estonia (EE)

Lithuania (LT)

United Kingdom (UK)

United States (US)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

 
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