Zoliflodacin

PubChem compound: 76685216

Active ingredient description

Zoliflodacin is an antibacterial drug. It is a spiropyrimidinetrione inhibitor of the bacterial type II topoisomerases (DNA gyrase and topoisomerase IV), which are required for DNA synthesis. Zoliflodacin binds within the cleaved DNA–gyrase complex, blocking re-ligation, and interacts with conserved amino acids in the gyrase B subunit.

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Document Type Information Source  
 NUZOLVENCE Oral suspension MPI, US: SPL/PLR FDA, National Drug Code (US)

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

DrugBank Drug: DB12817
KEGG Drug: D11726
PubChem Compound: 76685216
UNII Identifier: FWL2263R77
ZOLIFLODACIN

Medicines

Zoliflodacin is an active ingredient of these brands:

United States (US)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

 
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