ATC Group: J01CE Beta-lactamase sensitive penicillins

Semisynthetic antibiotic prepared by combining the sodium salt of penicillin G with N,N'-dibenzylethylenediamine. Benzathine benzylpenicillin binds to penicillin binding proteins (PBP), the enzymes that catalyze the synthesis of peptidoglycan, a critical component of the bacterial cell wall. This leads to the interruption of cell wall synthesis, consequently leading to bacterial cell growth inhibition and cell lysis.

Benzylpenicillin is a beta-lactam antibiotic. It is bacteriocidal by inhibiting bacterial cell wall biosynthesis. Penicillin resistance can be mediated by alteration of penicillin binding proteins or development of beta-lactamases.

Phenoxymethylpenicillin is a broad spectrum beta-lactam antibiotic. Phenoxymethylpenicillin binds to penicillin-binding proteins located on the inner membrane of the bacterial cell wall. Phenoxymethylpenicillin binds to and inactivates these proteins resulting in weakening of the bacterial cell wall and lysis.