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Benzathine benzylpenicillin

Also known as: Penicillin G benzathine

Brand names: BICILLIN C-R (in combination) BICILLIN L-A


Semisynthetic antibiotic prepared by combining the sodium salt of penicillin G with N,N'-dibenzylethylenediamine. Benzathine benzylpenicillin binds to penicillin binding proteins (PBP), the enzymes that catalyze the synthesis of peptidoglycan, a critical component of the bacterial cell wall. This leads to the interruption of cell wall synthesis, consequently leading to bacterial cell growth inhibition and cell lysis.

ATC Classification

Benzathine benzylpenicillin
J Antiinfectives for systemic use → J01 Antibacterials for systemic use → J01C Beta-lactam antibacterials, penicillins → J01CE Beta-lactamase sensitive penicillins

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