ATC Group: J01DC Second-generation cephalosporins

Cefaclor is a second-generation cephalosporin antibiotic. Cefaclor has no activity against Pseudomonas species or Acinetobacter species. Methicillin-resistant staphylococci and most strains of enterococci (eg, Str. faecalis) are resistant to cefaclor.

Cefotetan is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Cefotetan has activity in the presence of some beta-lactamases, both penicillinases and cephalosporinases, of gram-negative and gram-positive bacteria.

Cefoxitin is a beta-lactam antibiotic of the group of the second-generation cephalosporins.

Cefprozil belongs to a sub-group of beta-lactam antibiotics, cephalosporins. It is bactericidal and acts by inhibiting synthesis of bacterial cell wall. The bactericidal action of cefprozil results from inhibition of cell-wall synthesis.

Cefuroxime inhibits bacterial cell wall synthesis following attachment to penicillin binding proteins (PBPs). This results in the interruption of cell wall (peptidoglycan) biosynthesis, which leads to bacterial cell lysis and death.